A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

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dc.creatorOladele, Johnson O
dc.creatorAjayi, Ebenezer I
dc.creatorOyeleke, Oyedotun M
dc.creatorOladele, Oluwaseun T
dc.creatorOlowookere, Boyede D
dc.creatorAdeniyi, Boluwaji M
dc.creatorOyewole, Olu I
dc.creatorOladiji, Adenike T
dc.date.accessioned2020-09-18T00:34:33Z
dc.date.available2020-09-18T00:34:33Z
dc.date.created2020-09
dc.description.abstractenglishDespite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.spa
dc.format.extent17 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2020.e04897spa
dc.identifier.issn2405-8440spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S2405844020317400spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/13406
dc.language.isoengspa
dc.publisherHeliyonspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.localAbierto (Texto Completo)spa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectSARS-CoV-2spa
dc.subject.keywordAntiviralsspa
dc.subject.keywordPhytochemicalsspa
dc.subject.keywordMedicinal plantsspa
dc.subject.keywordBiochemistryspa
dc.subject.keywordEpidemiologyspa
dc.subject.keywordFood sciencespa
dc.subject.keywordHealth sciencesspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordToxicologyspa
dc.subject.keywordPhytochemistryspa
dc.subject.keywordEvidence based medicinespa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleA systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plantsspa
dc.type.coarhttp://purl.org/coar/resource_type/c_dcae04bcspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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