Matrix effect in pesticide analysis by ultra fast liquid chromatography coupled to mass spectrometry
Data
2012Autor
Ahumada, Diego A.
Zamudio, Adriana M.
España, Julio C.
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Resumo
In this work a study of several variables that affect the matrix effects (ME) was performed.
The choice was given among four extraction solvents and four different clean-up methods which
were compared in order to find the method that produces least ME and gives the highest response
for 18 compounds. Variability of ME under identical chromatographic conditions for five fruits
was also studied. Finally we evaluated different analyte/matrix ratios to assess the ME. The results
showed that the significantly better responses (P < 0.05) were achieved by using the mixture of
three absorbents and the use of only Graphitized Carbon Black causes greater suppression of
ionization. From the five matrices tested it was found that grapes and tomatoes extract induced a
larger ME, meanwhile the use of apple and mango matrices gave responses more like matrix-free
standards. Finally, a negative correlation between the suppression of ionization and the compound/
matrix ratio was found.
Palabras clave
Pesticides; Mass spectrometry; Liquid chromatography; Matrix effectLink para o recurso
https://doi.org/10.1590/S0103-50532012000400011Collections
- Año 2012 [126]
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