Two compounds of the Colombian algae Hypnea musciformis prevent oxidative damage in human low density lipoproteins LDLs
Fecha
2019Autor
Rozo, Gladys
Rozo, Claudia
Puyana, Mónica
Ramos, Freddy A.
Almonacid, Carmen
Castro, Henry
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Resumen
People of the Caribbean believe that red algae have properties that are beneficial to human health. We aimed to
test the beneficial properties of Hypnea musciformis by measuring its ability to prevent oxidation in human LDLs.
We obtained algal extracts via supercritical fluid extraction using 15 different combinations of pressure, temperature
and solvent polarity. We quantified phenol contents and measured antioxidant activity through ABTS
and TBARS assays. The ability of each extracted compound to protect LDLs against oxidative damage was
compared with that of natural vitamin E. The extracts obtained under low pressure (10–20 MPa) with 8%
ethanol provided 42% extra protection, while those obtained under high pressure (30 MPa) with 8% ethanol
provided 62.5% extra protection. The compounds responsible for this activity were purified through chromatography
and identified by 1HNMR spectroscopy as (−)-epicatechin and phloretin. Our results emphasize the
high potential of extracts of H. musciformis as functional foods.
Palabras clave
Algae; Lipidic peroxidation; Epicatechin; Phloretin; Supercritical fluid extractionEnlace al recurso
https://doi.org/10.1016/j.jff.2019.06.001Colecciones
- Año 2019 [125]
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