Innate and adaptive immune responses against coronavirus
Date
2020Author
Hosseini, Arezoo
Hashemi, Vida
Shomali, Navid
Asghari, Faezeh
Gharibi, Tohid
Akbari, Morteza
Gholizadeh, Saber
Jafari, Abbas
Metadata
Show full item recordAbstract
Coronaviruses (CoVs) are a member of the Coronaviridae family with positive-sense single- stranded RNA. In
recent years, the CoVs have become a global problem to public health. The immune responses (innate and
adaptive immunity) are essential for elimination and clearance of CoVs infections, however, uncontrolled immune responses can result in aggravating acute lung injury and significant immunopathology. Gaining profound
understanding about the interaction between CoVs and the innate and adaptive immune systems could be a
critical step in the field of treatment. In this review, we present an update on the host innate and adaptive
immune responses against SARS-CoV, MERS-CoV and newly appeared SARS-CoV-2.
Palabras clave
COVID-19; Innate immune response; Adaptive immune response; Monoclonal antibody therapy; Convalescent plasma therapyLink to resource
https://doi.org/10.1016/j.biopha.2020.110859Collections
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