SARS-CoV-2 seroprevalence among health care workers in a new york city hospital: A cross-sectional analysis during the COVID-19 pandemic
Fecha
2020Autor
Venugopal, Usha
Jilani, Nargis
Rabah, Sami
Shariff, Masood A.
Jawed, Muzamil
Mendez Batres, Astrid
Abubacker, Muhamed
Menon, Sharika
Pillai, Anjana
Shabarek, Nehad
Kasubhai, Moiz
Dimitrov, Vihren
Menon, Vidya
Resumen
Background
New York City (NYC) has endured the greatest burden of COVID-19 infections in the US.
Health inequities in South Bronx predisposed this community to a greater number of
infections cases, hospitalisations and mortality. Health Care Workers (HCWs) are at high-risk
of exposure to the infection. This study aims to assess seroprevalence and associated
characteristics of consenting HCWs from a NYC public hospital.
Methods
Cross sectional study including serum samples for qualitative SARS-CoV-2 antibody testing
with nasopharyngeal swabs for SARS-CoV-2 PCR and completion of an online survey
capturing demographics, COVID-19 symptoms during the preceding months on duty, details
of healthcare and community exposure, and travel history were collected from consenting
participants in May 2020. Participants’ risk of exposure to COVID-19 infection in hospital
and in the community was defined based on CDC guidelines. Travel history to high-risk areas
was also considered an additional risk. The Odds Ratio with bivariable and multivariable
logistic regression was used to assess characteristics associated with seroprevalence.
Results
A total of 500 HCW were tested, 137 (27%) tested positive for SARS-CoV-2 antibody.
Symptomatic participants had a 75% (98/130) rate of seroconversion compared to those
without symptoms. Subjects with anosmia and ageusia had increased odds of seroconversion
in comparison to those without these symptoms. Community exposure was 34% (44/130)
among those who had positive antibodies.
Conclusion
Seroprevalence among HCWs was high compared to the community at the epicenter of the
pandemic. Further studies to evaluate sustained adaptive immunity in this high-risk group
will guide our response to a future surge.
Palabras clave
Seroprevalence; Health care workers; Antibody; Exposure; SARS-CoV-2 PCR; COVID-19Enlace al recurso
https://doi.org/10.1016/j.ijid.2020.10.036Colecciones
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