The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series
Data
2020Autor
Zeng, Hao
Wang, Dongfang
Nie, Jingmin
Liang, Haoyu
Gu, Jiang
Zhao, Anne
Xu, Lixin
Lang, Chunhui
Cui, Xiaoping
Guo, Xiaolan
Zhou, Changlong
Li, Haibo
Guo, Bin
Zhang, Jinyong
Wang, Qiang
Fang, Li
Liu, Wen
Huang, Yishan
Mao, Wei
Chen, Yaokai
Zou, Quanming
Metadata
Mostrar registro completoResumo
Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral
infections. However, the quality control of CP and individual variation in patients in different studies make it rather difficult to
evaluate the efficacy and risk of CP therapy for coronavirus disease 2019 (COVID-19). We aimed to explore the potential efficacy
of CP therapy, and to assess the possible factors associated with its efficacy. We enrolled eight critical or severe COVID-19
patients from four centers. Each patient was transfused with 200–400 mL of CP from seven recovered donors. The primary
indicators for clinical efficacy assessment were the changes of clinical symptoms, laboratory parameters, and radiological image
after CP transfusion. CP donors had a wide range of antibody levels measured by serology tests which were to some degree
correlated with the neutralizing antibody (NAb) level. No adverse events were observed during and after CP transfusion.
Following CP transfusion, six out of eight patients showed improved oxygen support status; chest CT indicated varying degrees
of absorption of pulmonary lesions in six patients within 8 days; the viral load was decreased to a negative level in five patients
who had the previous viremia; other laboratory parameters also tended to improve, including increased lymphocyte counts,
decreased C-reactive protein, procalcitonin, and indicators for liver function. The clinical efficacy might be associated with CP
transfusion time, transfused dose, and the NAb levels of CP. This study indicated that CP might be a potential therapy for severe
patients with COVID-19.
Palabras clave
COVID-19; COVID-19 patients; Multi-center case series; Convalescent plasma therapyLink para o recurso
https://doi.org/10.1038/s41392-020-00329-xCollections
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