Comparison of nonhuman primates identified the suitable model for COVID-19
Date
2020Author
Lu, Shuaiyao
Zhao, Yuan
Yu, Wenhai
Yang, Yun
Gao, Jiahong
Wang, Junbin
Kuang, Dexuan
Yang, Mengli
Yang, Jing
Ma, Chunxia
Xu, Jingwen
Qian, Xingli
Li, Haiyan
Zhao, Siwen
Li, Jingmei
Wang, Haixuan
Long, Haiting
Zhou, Jingxian
Luo, Fangyu
Ding, Kaiyun
Wu, Daoju
Zhang, Yong
Dong, Yinliang
Liu, Yuqin
Zheng, Yinqiu
Lin, Xiaochen
Jiao, Li
Zheng, Huanying
Dai, Qing
Sun, Qiangming
Hu, Yunzhang
Ke, Changwen
Liu, Hongqi
Peng, Xiaozhong
Metadata
Show full item recordAbstract
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains challenging. Here, we characterized severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in three NHP species: Old World monkeys Macaca mulatta (M. mulatta)
and Macaca fascicularis (M. fascicularis) and New World monkey Callithrix jacchus (C. jacchus). Infected M. mulatta and M. fascicularis
showed abnormal chest radiographs, an increased body temperature and a decreased body weight. Viral genomes were detected
in swab and blood samples from all animals. Viral load was detected in the pulmonary tissues of M. mulatta and M. fascicularis but
not C. jacchus. Furthermore, among the three animal species, M. mulatta showed the strongest response to SARS-CoV-2, including
increased inflammatory cytokine expression and pathological changes in the pulmonary tissues. Collectively, these data revealed
the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M. mulatta as the most suitable for
modeling COVID-19.
Palabras clave
Nonhuman primates; COVID-19Link to resource
https://doi.org/10.1038/s41392-020-00269-6Collections
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