Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques
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2020-09-02Autor
Deng, Wei
Bao, Linlin
Gao, Hong
Xiang, Zhiguang
Qu, Yajin
Song, Zhiqi
Gong, Shuran
Liu, Jiayi
Liu, Jiangning
Yu, Pin
Qi, Feifei
Xu, Yanfeng
Li, Fengli
Xiao, Chong
Lv, Qi
Xue, Jing
Wei, Qiang
Liu, Mingya
Wang, Guanpeng
Wang, Shunyi
Yu, Haisheng
Chen, Ting
Liu, Xing
Zhao, Wenjie
Han, Yunlin
Qin, Chuan
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmitted through the respiratory route, but potential extra-respiratory routes of SARS-CoV-2 transmission remain uncertain. Here we inoculated five rhesus macaques with 1 × 106 TCID50 of SARS-CoV-2 conjunctivally (CJ), intratracheally (IT), and intragastrically (IG). Nasal and throat swabs collected from CJ and IT had detectable viral RNA at 1–7 days post-inoculation (dpi). Viral RNA was detected in anal swabs from only the IT group at 1–7 dpi. Viral RNA was undetectable in tested swabs and tissues after intragastric inoculation. The CJ infected animal had a higher viral load in the nasolacrimal system than the IT infected animal but also showed mild interstitial pneumonia, suggesting distinct virus distributions. This study shows that infection via the conjunctival route is possible in non-human primates; further studies are necessary to compare the relative risk and pathogenesis of infection through these different routes in more detail.
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SARS-CoV-2Link para o recurso
https://www.nature.com/articles/s41467-020-18149-6#article-infoCollections
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