Signal amplifcation by reversible exchange for COVID‐19 antiviral drug candidates
Data
2020Autor
Jeong, Hye Jin
Min, Sein
Chae, Heelim
Kim, Sarah
Lee, Gunwoo
Namgoong, Sung Keon
Jeong, Keunhong
Metadata
Mostrar registro completo
Documentos PDF
Resumo
Several drug candidates have been proposed and tested as the latest clinical treatment for coronavirus
pneumonia (COVID-19). Chloroquine, hydroxychloroquine, ritonavir/lopinavir, and favipiravir are
under trials for the treatment of this disease. The hyperpolarization technique has the ability to
further provide a better understanding of the roles of these drugs at the molecular scale and in
diferent applications in the feld of nuclear magnetic resonance/magnetic resonance imaging. This
technique may provide new opportunities in diagnosis and research of COVID-19. Signal amplifcation
by reversible exchange-based hyperpolarization studies on large-sized drug candidates were carried
out. We observed hyperpolarized proton signals from whole structures, due to the unprecedented
long-distance polarization transfer by para-hydrogen. We also found that the optimal magnetic
feld for the maximum polarization transfer yield was dependent on the molecular structure. We can
expect further research on the hyperpolarization of other important large molecules, isotope labeling,
as well as polarization transfer on nuclei with a long spin relaxation time. A clinical perspective of
these features on drug molecules can broaden the application of hyperpolarization techniques for
therapeutic studies
Palabras clave
COVID‑19; Antiviral drugsLink para o recurso
https://doi.org/10.1038/s41598-020-71282-6Collections
Estadísticas Google Analytics
Comments
Respuesta Comentario Repositorio Expeditio
Gracias por tomarse el tiempo para darnos su opinión.