Nanotechnological strategies for systemic microbial infections treatment: A review
Fecha
2020Autor
Santos Ramos, Matheus Aparecido dos
Santos, Karen Cristina dos
Silva, Patrícia Bento da
Toledo, Luciani Gaspar de
Marena, Gabriel Davi
Rodero, Camila Fernanda
Furquim de Camargo, Bruna Almeida
Capaldi Fortunato, Giovanna
Bauab, Taís Maria
Chorilli, Marlus
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Resumen
Systemic infections is one of the major causes of mortality worldwide, and a shortage of drug
approaches applied for the rapid and necessary treatment contribute to increase the levels of death in
affected patients. Several drug delivery systems based in nanotechnology such as metallic
nanoparticles, liposomes, nanoemulsion, microemulsion, polymeric nanoparticles, solid lipid
nanoparticles, dendrimers, hydrogels and liquid crystals can contribute in the biological performance
of active substances for the treatment of microbial diseases triggered by fungi, bacteria, virus and
parasites. In the presentation of these statements, this review article present and demonstrate the
effectiveness of these drug delivery systems for the treatment of systemic diseases caused by several
microorganisms, through a review of studies on scientific literature worldwide that contributes to
better information for the most diverse professionals from the areas of health sciences. The studies
demonstrated that the drug delivery systems described can contribute to the therapeutic scenario of
these diseases, being classified as safe, active platforms and with therapeutic versatility.
Palabras clave
Systemic infections; Sepsis treatment; Nanotechnology; Drug delivery systemsEnlace al recurso
https://doi.org/10.1016/j.ijpharm.2020.119780Colecciones
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