Laboratory diagnosis of COVID-19
Documentos PDF
Resumo
Objectives: This was a non-systematic review of the literature on the laboratory diagnosis of
COVID-19.
Data sources: Searches in PubMed and Google Scholar for articles made available in 2020, using
the terms diagnosis ¨ OR¨ diagnostic’’ ¨ OR diagnostic ¨ testsOR¨ ¨testsAND ¨ COVID-19 ¨ OR¨ ¨SARS-CoV-2¨in
the title.
Summary of findings: Tests for the etiological agent identify genetic material of SARS-CoV-2 or
humoral responses to it. The gold standard for diagnosis is the identification of viral genome targets by real-time polymerase chain reaction (RT-PCR) in respiratory tract materials during the
first week of symptoms. Serological tests should be indicated from the second week of symptoms
onwards. A wide range of different tests is available, with variable sensitivity and specificity,
most of which require validation. Laboratory tests such as complete blood count, C-reactive
protein (CRP), D-dimer, clotting tests, lactic dehydrogenase (LDH), ferritin, and procalcitonin
identify risk of disease with greater severity, thromboembolic complications, myocardial damage, and/or worse prognosis. Imaging tests may be useful for diagnosis, especially when there
is a compatible clinical picture, and other tests presented negative results or were unavailable.
Conclusions: The identification of genetic material of the virus by RT-PCR is the gold standard
test, but its sensitivity is not satisfactory. The diagnosis of COVID-19 should be based on clinical
data, epidemiological history, tests for etiological diagnosis, and tests to support the diagnosis
of the disease and/or its complications. New diagnostic methods with higher sensitivity and
specificity, as well as faster results, are necessary.
© 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. This is an open
access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/
4.0/).
Palabras clave
Diagnosis; Diagnostic tests; Diagnostic techniques and procedures; COVID-19; CoronavirusLink para o recurso
https://doi.org/10.1016/j.jped.2020.08.001Collections
Estadísticas Google Analytics
Comments
Respuesta Comentario Repositorio Expeditio
Gracias por tomarse el tiempo para darnos su opinión.