Can a metabolism-targeted therapeutic intervention successfully subjugate coronavirus? A scientific rational
Data
2020Autor
Mansouri, Kamran
Rastegari-Pouyani, Mohsen
Ghanbri-Movahed, Maryam
Safarzadeh, Mehrnoush
Kiani, Sara
Ghanbari-Movahed, Zahra
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Resumo
As a process entailing a high turnover of the host cell molecules, viral replication is required for a
successful viral infection and requests virus capacity to acquire the macromolecules required for its
propagation. To this end, viruses have adopted several strategies to harness cellular metabolism in
accordance with their specific demands. Most viruses upregulate specific cellular anabolic pathways
and are largely dependent on such alterations. RNA viruses, for example, upregulate both
glycolysisand glycogenolysis providing TCA cycle intermediates essential for anabolic lipogenesis.
Also, these infections usually induce the PPP, leading to increased nucleotide levels supporting viral
replication. SARS-CoV-2 (the cause of COVID-19)that has so far spread from China throughout the
world is also an RNA virus. Owing to the more metabolic plasticity of uninfected cells, a promising
approach for specific antiviral therapy, which has drawn a lot of attention in the recent years,
would be the targeting of metabolic changes induced by viruses. In the current review, we first
summarize some of virus-induced metabolic adaptations and then based on these information as
well as SARS-CoV-2 pathogenesis, propose a potential therapeutic modality for this calamitous
world-spreading virus with the hope of employing this strategy for near-future clinical application.
Palabras clave
SARS-CoV-2; Cellular metabolism; Glycolysis; PPP; TCA cycleLink para o recurso
https://doi.org/10.1016/j.biopha.2020.110694Collections
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