Immune literacy: reading, writing and editing adaptive immunity
Date
2020Author
Csepregi, Lucia
Ehling, Roy
Wagner, Bastian
Reddy, Sai T.
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Abstract
Advances in reading, writing and editing DNA are providing unprecedented insights into the complexity of
immunological systems. This combination of systems and synthetic biology methods is enabling the
quantitative and precise understanding of molecular recognition in adaptive immunity, thus providing a
framework for reprogramming immune responses for translational medicine. In this review, we will
highlight state-of-the-art methods such as immune repertoire sequencing, immunoinformatics and
immunogenomic engineering and their application towards adaptive immunity. We showcase novel and
interdisciplinary approaches that have the promise of transforming the design and breadth of molecular
and cellular immunotherapies.
Palabras clave
Immune literacy; Adaptive immunityLink to resource
https://doi.org/10.1016/j.isci.2020.101519Collections
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