Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2
Fecha
2020Autor
Levy Jean, Bernard I
Fauvel, Pierre
Documentos PDF
Imagenes y Videos
Resumen
Severe acute respiratory syndrome coronavirus 2, which is responsible for the current coronavirus
disease 2019 pandemic, uses angiotensin-converting enzyme 2 as a gateway into host cells. In this
review, we summarize the biology of this enzyme, which plays a key role in cardiovascular
homeostasis. Blockers of the renin-angiotensin system modify the expression and activity of
angiotensin-converting enzyme 2 in different ways. The effects of angiotensin-converting enzyme
inhibitors and angiotensin receptor blockers on the expression and enzyme activity of angiotensinconverting enzyme 2 are reviewed, and the consequences of these treatments for the severity of
coronavirus disease 2019 infection are discussed.
Abbreviations: ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme 2; Ang,
angiotensin; ARB: angiotensin II receptor blocker; AT1 receptor: angiotensin II receptor type 1;
COVID-19: coronavirus disease 2019; RAS: renin-angiotensin system; SARS-CoV-2, severe acute
respiratory syndrome coronavirus 2.
Palabras clave
Angiotensin-converting; Angiotensin receptor blockers; Arterial hypertension; Heart failureEnlace al recurso
https://doi.org/doi:10.1016/j.acvd.2020.07.001Colecciones
Estadísticas Google Analytics
Comentarios
Respuesta Comentario Repositorio Expeditio
Gracias por tomarse el tiempo para darnos su opinión.