Coagulation dysfunction in COVID-19: the interplay between inflammation, viral infection and the coagulation system
Fecha
2020Autor
Lazzaroni, Maria Grazia
Piantoni, Silvia
Masneri, Stefania
Garrafa, Emirena
Martini, Giuliana
Tincani, Angela
Andreoli, Laura
Franceschini, Franco
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Resumen
COVID-19 is a new pandemic, caused by Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-Cov2)
infection and characterized by a broad spectrum of clinical manifestations.
Inflammation and the innate immune system have been recently recognized as pivotal players in the most
severe forms, characterized by significantly elevated levels of pro-inflammatory cytokines. In this setting,
several studies have also reported the presence of abnormalities in coagulation parameters and platelets
count, possibly identifying a subgroup of patients with poor prognosis. Some reports of full-blown
thromboembolic events are emerging.
Among the possible mechanisms underlying coagulation dysfunction, the so-called cytokine storm seems to
play a pivotal role. Other candidate factors include virus-specific mechanisms, related to the virus interaction
with renin angiotensin system (RAS) and the fibrinolytic pathway, but also comorbidities affecting these
patients.
Coagulation dysfunction is therefore a candidate risk factor for adverse outcomes in COVID-19 and should
be carefully addressed in clinical practice.
Palabras clave
COVID-19; SARS-CoV2; Coagulation; Thrombosis; InflammationEnlace al recurso
https://doi.org/10.1016/j.blre.2020.100745Colecciones
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