Evaluation of rapid antigen test for detection of SARS-CoV-2 virus
Data
2020Autor
Mak, Gannon CK
Cheng, Peter KC
Lau, Stephen SY
Wong, Kitty KY
Lau, CS
Lam, Edman TK
Chan, Rickjason CW
Tsang, Dominic NC
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Resumo
Background: The rapid diagnosis of Coronavirus Disease 2019 (COVID-19) patients is essential to reduce the
disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests.
Objective: To evaluate the performance of the commercially available BIOCREDIT COVID-19 Ag test and compare it with RT-PCR for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus.
Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture
and RT-PCR as reference methods. The RAD test was further evaluated using respiratory samples collected from
confirmed COVID-19 patients. The results were compared with RT-PCR test.
Results: The detection limits between RAD test, viral culture and RT-PCR varied hugely. RAD was 103 fold less
sensitive than viral culture while RAD was 105 fold less sensitive than RT-PCR. The RAD test detected between
11.1 % and 45.7 % of RT-PCR-positive samples from COVID-19 patients.
Conclusions: This study demonstrated that the RAD test serves only as adjunct to RT-PCR test because of potential for false-negative results.
Palabras clave
2019 novel coronavirus; SARS-CoV-2; COVID-19; Rapid antigen detection; RT-PCR; Viral cultureLink para o recurso
https://doi.org/10.1016/j.jcv.2020.104500Collections
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