Gastrointestinal symptoms as a major presentation component of a novel multisystem inflammatory syndrome in children (MIS-C) that is related to COVID-19: a single center experience of 44 cases
Data
2020Autor
Miller, Jonathan
Cantor, Amanda
Zachariah, Philip
Ahn, Danielle
Martinez, Mercedes
Margolis, Kara
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Resumo
Until recently, the clinical course of coronavirus disease 2019 (COVID-19) in
children has been reported to be largely mild.1,2 Recently, it has become evident that a subset of
children exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can
become critically ill with a condition now referred to as multisystem inflammatory syndrome in
children (MIS-C), characterized by systemic hyperinflammation with fever and multi-system
organ dysfunction.3
Gastrointestinal symptoms are increasingly recognized to be associated
with the presentation of MIS-C, potentially confusing the diagnosis of MIS-C with other common,
less toxic gastrointestinal infections and even inflammatory bowel disease. In the first published
correspondence describing MIS-C in eight patients from the United Kingdom, 100% presented
with GI symptoms.4
Similarly 6 of 10 patients from an Italian cohort had GI issues.5
This is In
contrast to adults, who most commonly present with respiratory symptoms, and report GI
symptoms in <10-15% of cases.6,7 We examined whether similar presentations and prevalence
extended to our comparatively larger U.S. cohort of 44 patients (<21 years old) with MIS-C.
Palabras clave
Gastrointestinal symptoms; Novel multisystem inflammatory; Syndrome in children (MIS-C); COVID-19Link para o recurso
https://doi.org/10.1053/j.gastro.2020.05.079Collections
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