Using a diagnostic model based on routine laboratory tests to distinguish patients infected with SARS-CoV-2 from those infected with influenza virus
Data
2020Autor
Luo, Ying
Yuan, Xu
Xue, Ying
Mao, Liyan
Lin, Qun
Tang, Guoxing
Song, Huijuan
Liu, Weiyong
Hou, Hongyan
Wang, Feng
Sun, Ziyong
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Resumo
Background: The differential diagnosis between novel coronavirus pneumonia patients (NCPP) and
influenza patients (IP) remains a challenge in clinical practice.
Methods: Between January 2018 and March 2020, 1,027 NCPP and 1,140 IP were recruited from Tongji
hospital. Routine blood examination, biochemical indicators and coagulation function analysis were
simultaneously performed in all participants.
Results: There was no sex predominance in NCPP. The NCPP were frequently encountered in the sixth and
seventh decades of life. The mean age of NCPP (56 16 years) was higher than IP (47 17 years), but
without statistical difference. Although most results of routine laboratory tests between NCPP and IP had
no significant differences, some laboratory tests showed an obvious change in NCPP. It was observed that
NCPP had significantly decreased white blood cells, alkaline phosphatase and d-dimer compared with IP.
However, the results of lactate dehydrogenase, erythrocyte sedimentation rate and fibrinogen were
significantly increased in NCPP compared with IP. The diagnostic model based on a combination of 18
routine laboratory indicators showed an area under the curve of 0.796 (95% CI, 0.777–0.814), with a
sensitivity of 46.93% and specificity of 90.09% when using a cut-off value of 0.598.
Conclusions: Some routine laboratory results had statistical difference between NCPP and IP. A diagnostic
model based on a combination of routine laboratory results provided an adjunct approach in the
differential diagnosis between NCPP and IP.
Palabras clave
SARS-CoV-2; Influenza virus; Novel coronavirus pneumonia patients; Influenza patients; Laboratory testsLink para o recurso
https://doi.org/10.1016/j.ijid.2020.04.078Collections
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