Vaccine development against coronavirus (2003 to present): An overview, recent advances, current scenario, opportunities and challenges
Date
2020Author
Badgujar, Kirtikumar C.
Badgujar, Vivek C.
Badgujar, Shamkant B.
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Abstract
Background and aim: The pandemic COVID-19 occurring due to novel emerging coronavirus2019 (SARS-CoV-2) is severely affecting the worldwide public health, culture, economy and
human social behaviour. Till date, there is no approved medicine/ treatment to cure COVID-19,
whereas, vaccine development efforts are going on high priority. This review aimed to provide an
overview of prior art, recent advances, vaccine designing strategies, current scenario, opportunities
and challenges related to development of coronavirus vaccine.
Method: A literature survey was conducted using Scopus, PubMed and Google Scholar with the
search key as: coronavirus vaccine, SARS vaccine, MERS vaccine and COVID-19 vaccine. Articles
related to above search query were retrieved, sorted, analyzed and developed into an easy-tounderstand review.
Results: The genome phylogenetic analysis suggested that genomic sequence of SARS-CoV-2 is
almost 80 % similar to that of SARS-CoV, further both these viruses bind to same host cell receptor
ACE-2. Hence it is expected that, previously available literature data about coronavirus vaccine
designing may play crucial role in development of rapid vaccine against COVID-19. In view of this,
the present review discuss (i) existing information (from 2003 to present) about the type of vaccine,
antigen, immunogenic response, animal model, route of administration, adjuvants and current
scenario for designing of coronavirus vaccine (ii) potential factors and challenges related to rapid
development of COVID-19 vaccine. Conclusion: In conclusion, we suggest possible target sites for designing of vaccine against SARSCoV-2 virus.
Palabras clave
Coroanvirus disease vaccine; COVID-19 vaccine; Antigens; Adjuvants; Spike proteinLink to resource
https://doi.org/10.1016/j.dsx.2020.07.022Collections
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