Covid-19 pandemic and current medical interventions
Data
2020Autor
Manhas, Sweeta
Anjali, Anjali
Mansoor, Sheikh
Sharm, Vikas
Rehman, Muneeb U.
Ahmad, Parvaiz
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Resumo
First humanoid coronavirus was discovered in the middle of 1960s, the class of viruses
are considered to be a huge threat. The first onset of human coronavirus, SARS
(SARS-CoV) appeared in 2003 which spanned five continents having lethal effects on human population accompanied by The Middle East Respiratory Syndrome Coronavirus in
2012 with a death rate of 35%. The viruses remain a threat till date and are of serious
concern since no vaccine or specified drug therapy has been approbated for treating human coronaviruses. The viruses became a pandemic worldwide with the emergence of
Wuhan coronavirus (2019-nCoV). SARS-CoV2 viral manifestation poses a serious human life risk by causing acute lung injury and various respiratory outcomes and has
become a global concern. High pathogenicity and transmission rate of the viral strain
has become the spotlight of research community throughout the world. With the ongoing
studies on viral structure and host interactions, the intricacy of the viral proteome structure and replication cycle proposes a need to explore our understanding of host factors
playing role in viral multiplication cycle. This review provides insight into our prevalent
perception of coronavirus-host interactions, structure of SARS-CoV2, receptor mediated
entry of virus inside the human cells, ongoing clinical trials, drug therapies and treatments that are being used to combat COVID-19 targeting viral fusion, replication and
its multiplication.
Palabras clave
Covid-19; Pandemic; Current Medical InterventionsLink para o recurso
https://doi.org/10.1016/j.arcmed.2020.05.007Collections
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