Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia
Date
2020-07-06Author
De Biasi, Sara
Meschiari, Marianna
Gibellini, Lara
Bellinazzi, Caterina
Borella, Rebecca
Fidanza, Lucia
Gozzi, Licia
Iannone, Anna
Lo Tartaro, Domenico
Mattioli, Marco
Paolini, Annamaria
Menozzi, Marianna
Milić, Jovana
Franceschi, Giacomo
Fantini, Riccardo
Tonelli, Roberto
Sita, Marco
Sarti, Mario
Trenti, Tommaso
Brugioni, Lucio
Cicchetti, Luca
Facchinetti, Fabio
Pietrangelo, Antonello
Clini, Enrico
Girardis, Massimo
Guaraldi, Giovanni
Mussini, Cristina
Cossarizza, Andrea
Metadata
Show full item record
Documentos PDF
Summary in foreign language
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia are urgently required. Here we show that, compared with healthy controls, COVID-19 patients’ T cell compartment displays several alterations involving naïve, central memory, effector memory and terminally differentiated cells, as well as regulatory T cells and PD1+CD57+ exhausted T cells. Significant alterations exist also in several lineage-specifying transcription factors and chemokine receptors. Terminally differentiated T cells from patients proliferate less than those from healthy controls, whereas their mitochondria functionality is similar in CD4+ T cells from both groups. Patients display significant increases of proinflammatory or anti-inflammatory cytokines, including T helper type-1 and type-2 cytokines, chemokines and galectins; their lymphocytes produce more tumor necrosis factor (TNF), interferon-γ, interleukin (IL)-2 and IL-17, with the last observation implying that blocking IL-17 could provide a novel therapeutic strategy for COVID-19.
Palabras clave
NeumoníaLink to resource
https://www.nature.com/articles/s41467-020-17292-4Collections
Estadísticas Google Analytics
Comments
Respuesta Comentario Repositorio Expeditio
Gracias por tomarse el tiempo para darnos su opinión.