A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2
Date
2020-05-26Author
Shi, Rui
Shan, Chao
Duan, Xiaomin
Chen, Zhihai
Liu, Peipei
Song, Jinwen
Song, Tao
Bi, Xiaoshan
Han, Chao
Wu, Lianao
Gao, Ge
Hu, Xue
Zhang, Yanan
Tong, Zhou
Huang, Weijin
Liu, William Jun
Wu, Guizhen
Zhang, Bo
Wang, Lan
Qi, Jianxun
Feng, Hui
Wang, Fu sheng
Wang, Qihui
Gao, George Fu
Yuan, Zhiming
Yan, Jinghua
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Summary in foreign language
An outbreak of coronavirus disease 2019 (COVID-19)1,2,3, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4, has spread globally. Countermeasures are needed to treat and prevent further dissemination of the virus. Here we report the isolation of two specific human monoclonal antibodies (termed CA1 and CB6) from a patient convalescing from COVID-19. CA1 and CB6 demonstrated potent SARS-CoV-2-specific neutralization activity in vitro. In addition, CB6 inhibited infection with SARS-CoV-2 in rhesus monkeys in both prophylactic and treatment settings. We also performed structural studies, which revealed that CB6 recognizes an epitope that overlaps with angiotensin-converting enzyme 2 (ACE2)-binding sites in the SARS-CoV-2 receptor-binding domain, and thereby interferes with virus–receptor interactions by both steric hindrance and direct competition for interface residues. Our results suggest that CB6 deserves further study as a candidate for translation to the clinic.
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Anticuerpos neutralizantes humanosLink to resource
https://www.nature.com/articles/s41586-020-2381-yCollections
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