Hematological features of persons with COVID-19
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2020-06-11Autor
Li, Qiubai
Cao, Yulin
Chen, Lei
Wu, Di
Yu, Jianming
Wang, Hongxiang
He, Wenjuan
Chen, Li
Dong, Fang
Chen, Weiqun
Chen, Wenlan
Li, Lei
Ran, Qijie
Liu, Qiaomei
Ren, Wenxiang
Gao, Fei
Chen, Zhichao
Gale, Robert Peter
Hu, Yu
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Resumo em língua estrangeira
We studied admission and dynamic demographic, hematological and biochemical co-variates in 1449 hospitalized subjects with coronavirus infectious disease-2019 (COVID-19) in five hospitals in Wuhan, Hubei province, China. We identified two admission co-variates: age (Odds Ratio [OR] = 1.18, 95% Confidence Interval [CI] [1.02, 1.36]; P = 0.026) and baseline D-dimer (OR = 3.18 [1.48, 6.82]; P = 0.003) correlated with an increased risk of death in persons with COVID-19. We also found dynamic changes in four co-variates, Δ fibrinogen (OR = 6.45 [1.31, 31.69]; P = 0.022), Δ platelets (OR = 0.95 [0.90–0.99]; P = 0.029), Δ C-reactive protein (CRP) (OR = 1.09 [1.01, 1.18]; P = 0.037), and Δ lactate dehydrogenase (LDH) (OR = 1.03 [1.01, 1.06]; P = 0.007) correlated with an increased risk of death. The potential risk factors of old age, high baseline D-dimer, and dynamic co-variates of fibrinogen, platelets, CRP, and LDH could help clinicians to identify and treat subjects with poor prognosis.
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Hematological; hospitals in WuhanLink para o recurso
https://www.nature.com/articles/s41375-020-0910-1Collections
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