Pernio-like skin lesions associated with COVID-19: a case series of 318 patients from 8 countries
Data
2020Autor
Freeman, Esther E.
McMahon, Devon E.
Lipof, Jules B.
Rosenbach, Misha
Kovarik, Carrie
Takeshita, Junko
French, Lars E.
Thiers, Bruce H.
Hruza, George J.
Fox, Lindy P.
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Resumo
Background: Increasing evidence suggests pernio-like lesions are cutaneous manifestations of COVID-19.
Objective: To describe clinical and pathologic findings of pernio-like lesions in confirmed or suspected COVID-19
cases.
Methods: An international dermatology registry was circulated to healthcare providers worldwide through the
American Academy of Dermatology (AAD), International League of Dermatologic Societies (ILDS), and other
organizations.
Results: We documented 505 patients with dermatologic manifestations associated with COVID-19, including
318 (63%) with pernio-like lesions. Patients with pernio-like lesions were generally young and healthy, with
relatively mild COVID-19. Of 318 cases confirmed or suspected as COVID-19 by providers, twenty-three cases
(7%) were laboratory-confirmed COVID-19 positive, and 20 others (6%) were close contacts of confirmed COVID19 cases. Given current testing criteria, many patients lacked COVID-19 testing access. For 55% of patients,
pernio-like lesions were their only symptom. In patients with other COVID-19 symptoms, pernio-like lesions
typically appeared after other symptoms. Pernio-like lesions lasted a median of 14 days (IQR 10-21).
Limitations: A case series cannot estimate population level incidence or prevalence. Additionally, there may be
confirmation bias in reporting. We cannot exclude an epiphenomenon.
Conclusions: Pernio-like skin changes of the feet and hands, without another explanation, may suggest COVID19 infection and should prompt confirmatory testing.
Palabras clave
Skin lesions; COVID-19Link para o recurso
https://doi.org/10.1016/j.jaad.2020.05.109Collections
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