From SARS to COVID-19: What we have learned about children infected with COVID-19
Date
2020Author
Zhou, Meng-Yao
Xie, Xiao-Li
Peng, Yong-Gang
Wu, Meng-Jun
Deng, Xiao-Zhi
Wu, Ying
Xiong, Li-Jing
Shang, Li-Hong
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Abstract
Introduction: Coronaviruses, both SARS-CoV and SARS-CoV-2, first appeared in China. They have certain
biological, epidemiological and pathological similarities. To date, research has shown that their genes
exhibit 79% of identical sequences and the receptor-binding domain structure is also very similar. There
has been extensive research performed on SARS; however, the understanding of the pathophysiological
impact of coronavirus disease 2019 (COVID-19) is still limited.
Methods: This review drew upon the lessons learnt from SARS, in terms of epidemiology, clinical
characteristics and pathogenesis, to further understand the features of COVID-19.
Results: By comparing these two diseases, it found that COVID-19 has quicker and wider transmission,
obvious family agglomeration, and higher morbidity and mortality. Newborns, asymptomatic children
and normal chest imaging cases emerged in COVID-19 literature. Children starting with gastrointestinal
symptoms may progress to severe conditions and newborns whose mothers are infected with COVID-19
could have severe complications. The laboratory test data showed that the percentage of neutrophils and
the level of LDH is higher, and the number of CD4+ and CD8+T-cells is decreased in children's COVID-19
cases.
Palabras clave
Coronavirus; SARS; COVID-19; SARS-CoV-2; 2019-nCoV; ChildrenLink to resource
https://doi.org/10.1016/j.ijid.2020.04.090Collections
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