Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis
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Resumo
Background/Purpose: Current studies on pediatric coronavirus disease 2019 (COVID-19) are
rare. The clinical characteristics and spectrum are still unknown. Facing this unknown and
emerging pathogen, we aimed to collect current evidence about COVID-19 in children.
Methods: We performed a systematic review in PubMed and Embase to find relevant case
series. Because some reports were published in Chinese journals, the journals and publications
of the Chinese Medical Association related to COVID-19 were completely reviewed. A random
effects model was used to pool clinical data in the meta-analysis.
Results: Nine case series were included. In the pooled data, most of patients (75%) had a
household contact history. The disease severity was mainly mild to moderate (98%). Only 2
children (2%) received intensive care. Fever occurred in 59% of the patients, while cough in
46%. Gastrointestinal symptoms (12%) were uncommon. There are 26% children are asymptomatic. The most common radiographic finding was ground glass opacities (48%). Currently, there
is no evidence of vertical transmission to neonates born to mothers with COVID-19. Compared
with the most relevant virus, SARS-CoV, SARS-CoV-2 causes less severe disease.
Conclusion: COVID-19 has distinct features in children. The disease severity is mild. Current
diagnosis is based mainly on typical ground glass opacities on chest CT, epidemiological suspicion and contact tracing.
Palabras clave
Children; COVID-19; SARS-CoV-2Link para o recurso
https://doi.org/10.1016/j.jfma.2020.04.007Collections
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