Rajarshi, Keshav
Khan, Rajni
Singh, Mrityunjay K
Ranjan, Tushar
Ray, Sandipan
Ray, Shashikant
2020-11-24T20:37:43Z
2020-11-24T20:37:43Z
2020
0378-1119
https://doi.org/10.1016/j.gene.2020.145313
http://hdl.handle.net/20.500.12010/16010
The whole world is still suffering substantially from the coronavirus disease 2019 (COVID19) outbreak. Several protein-based molecules that are associated with the Severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which are essential for its functionality,
survival, and pathogenesis have been identified and are considered as potential therapeutic
targets. These protein-based molecules are either structural/non-structural components of
SARS-CoV-2 or host factors, which play a crucial role in this infection. Developing drug
molecules against these essential functional molecules to hinder their regular functioning and
associated physiological pathways could be promising for successful clinical management of
this novel coronavirus infection. The review aims to highlight the functional molecules that
play crucial roles in SARS-CoV-2 pathogenesis. We have emphasized how these potential
druggable targets could be beneficial in tackling the COVID-19 crisis.
32 páginas
application/pdf
eng
Gene Gene
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Therapeutic target
COVID-19
Pathogenesis
Spike proteins
TMPRSS2
Essential functional molecules associated with SARS-CoV-2 infection: Poten‐ tial therapeutic targets for COVID-19
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
Abierto (Texto Completo)
https://doi.org/10.1016/j.gene.2020.145313
http://purl.org/coar/resource_type/c_2df8fbb1