Newton, Hayley
Hartland, Elizabeth
Machner, Matthias
2020-10-06T03:30:06Z
2020-10-06T03:30:06Z
2018
978-2-88945-661-1
1664-8714
https://www.frontiersin.org/research-topics/4989/biology-and-pathogenesis-of-legionella
http://hdl.handle.net/20.500.12010/14227
181 páginas
application/pdf
eng
Frontiers Media SA
Internal medicine
Science (General)
Biology and Pathogenesis of Legionella
Libro
Legionnaires' Disease
Intravacuolar pathogen
Host-Pathogen Interactions
info:eu-repo/semantics/openAccess
Abierto (Texto Completo)
Dot/Icm effector
Legionella
10.3389/978-2-88945-661-1
Newton, H., Hartland, E., Machner, M., eds. (2018). Biology and Pathogenesis of Legionella. Lausanne: Frontiers Media. doi: 10.3389/978-2-88945-661-1
Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms.Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle.This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.
http://purl.org/coar/resource_type/c_2f33
https://creativecommons.org/licenses/by/4.0/