Waked, R.
Makhoul, J.
Saliba, G.
Chehata, N.
Mortada, S.
Zoghbi, A.
Choucair, J.
Haddad, E.
2020-09-28T17:37:49Z
2020-09-28T17:37:49Z
2020
2052-2975
https://doi.org/10.1016/j.nmni.2020.100750
http://hdl.handle.net/20.500.12010/13922
The coronavirus disease 2019 (COVID-19) pandemic is redefining the world we live in, and scientists are struggling to find the best severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic tool. Routine testing is currently performed using real-time reverse
transcription PCR (RT-PCR) of upper or lower respiratory tract secretions. We sought to demonstrate the importance of conducting
RT-PCR using deep sampling when initial upper respiratory testing is negative in cases of high index of suspicion for COVID-19. We
present the case of a 47-year-old man admitted for fever and bilateral pneumonia diagnosed via chest computed tomographic scan amidst
the early peak of the COVID-19 pandemic, suggesting a SARS-CoV-2 infection. Two RT-PCR results from nasopharyngeal swab samples
were negative. A bronchoscopy was then performed, and RT-PCR testing on bronchoalveolar lavage samples yielded positive results,
confirming the diagnosis of COVID-19 pneumonia. RT-PCR samples of the lower respiratory tract likely contain a higher virus load and
thus retain a higher sensitivity for SARS-CoV-2 detection.
3 páginas
application/pdf
eng
New Microbe and New Infect
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Coronavirus
COVID-19
Pneumonia
Polymerase chain reaction
SARS-CoV-2
Are two consecutive negative RT-PCR results enough to rule out COVID-19?
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
Abierto (Texto Completo)
https://doi.org/10.1016/j.nmni.2020.100750
http://purl.org/coar/resource_type/c_2df8fbb1