Zhang, Aining
Leng, Yan
Zhang, Yi
Wu, Kefan
Ji, Yelong
Lei, Shaoqing
Xia, Zhongyuan
2020-09-18T01:25:35Z
2020-09-18T01:25:35Z
2020-09-15
1201-9712
https://www.sciencedirect.com/science/article/pii/S1201971220307372
http://hdl.handle.net/20.500.12010/13416
24 páginas
application/pdf
eng
International Journal of Infectious Diseases
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Coronavirus
Meta-Analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
Abierto (Texto Completo)
Coagulation parameters
Coagulopathy
Laboratory
Prognosis
https://doi.org/10.1016/j.ijid.2020.09.021
Background
To figure out whether abnormal coagulation parameters are associated with disease severity and poor prognosis in patients with 2019 Corona Virus Disease (COVID-19).
Methods
A systematic literature search was conducted using the databases PubMed, Embase, and Web of sciences until April 25, 2020. We included a total of 15 studies with 2277 patients. Platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D) and fibrinogen (FIB) were collected and analyzed. The statistical results were expressed the effect measure by mean difference (MD) with the related 95% confidence interval (CI).
Results
The PLT level of severe patients was lower than that of mild patients, while the levels of PT, D-D and FIB were higher than those of mild patients (P < 0.05). The level of APTT had no statistical difference between two groups (P > 0.05). Compared to Non-ICU patients, PT of ICU patients was significantly longer (P < 0.05). In Non-survivors, PT and D-D were higher, yet PLT was lower than survivors (P < 0.05). There was no significant difference in APTT between survivors and Non-survivors (P > 0.05). The funnel plot and Egger's Regression test demonstrated that there was no publication bias.
Conclusions
Our data support the notion that coagulopathy could be considered as a risk factor for disease severity and mortality of COVID-19, which may help clinicians to identify the incidence of poor outcomes in COVID-19 patients.
http://purl.org/coar/resource_type/c_6501