Riksen, Niels P.
Netea, Mihai G.
2020-09-15T19:43:38Z
2020-09-15T19:43:38Z
2020
0098-2997
https://doi.org/10.1016/j.mam.2020.100897
http://hdl.handle.net/20.500.12010/13282
Innate immune cells can adopt long-term inflammatory phenotypes following brief encounters with exogenous
(microbial) or endogenous stimuli. This phenomenon is named trained immunity and can improve host defense
against (recurrent) infections. In contrast, trained immunity can also be maladaptive in the context of chronic
inflammatory disorders, such as atherosclerosis. Key to future therapeutic exploitation of this mechanism is
thorough knowledge of the mechanisms driving trained immunity, which can be used as pharmacological targets.
These mechanisms include profound changes in intracellular metabolism, which are closely intertwined with
epigenetic reprogramming at the level of histone modifications. Glycolysis, glutamine replenishment of the
tricarboxylic acid cycle with accumulation of fumarate, and the mevalonate pathway have all been identified as
critical pathways for trained immunity in monocytes and macrophages. In this review, we provide a state-of-theart overview of how these metabolic pathways interact with epigenetic programs to develop trained immunity.
9 páginas
application/pdf
eng
Molecular Aspects of Medicine
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Immunometabolic control
Trained immunity
Immunometabolic control of trained immunity
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
Abierto (Texto Completo)
https://doi.org/10.1016/j.mam.2020.100897
http://purl.org/coar/resource_type/c_2df8fbb1