Ma, Jingbo
Gu, Yang
Xu, Peng
2020-08-25T20:45:54Z
2020-08-25T20:45:54Z
2020
0958-1669
https://doi.org/10.1016/j.copbio.2020.07.008
http://hdl.handle.net/20.500.12010/12259
Natural products continue to be the inspirations for us to
discover and acquire new drugs. The seemingly unstoppable
viruses have kept records high to threaten human health and
well-being. The diversity and complexity of natural products
(NPs) offer remarkable efficacy and specificity to target viral
infection steps and serve as excellent source for antiviral
agents. The discovery and production of antiviral NPs remain
challenging due to low abundance in their native hosts.
Reconstruction of NP biosynthetic pathways in microbes is a
promising solution to overcome this limitation. In this review,
we surveyed 23 most prominent NPs (from more than
200 antiviral NP candidates) with distinct antiviral mode of
actions and summarized the recent metabolic engineering
effort to produce these compounds in various microbial hosts.
We envision that the scalable and low-cost production of novel
antiviral NPs, enabled by metabolic engineering, may light the
hope to control and eradicate the deadliest viruses that plague
our society and humanity.
10 páginas
application/pdf
eng
Current Opinion in Biotechnology
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Engineering antiviral
Natural products
Microbes
A roadmap to engineering antiviral natural products synthesis in microbes
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
Abierto (Texto Completo)
https://doi.org/10.1016/j.copbio.2020.07.008
http://purl.org/coar/resource_type/c_2df8fbb1