Vavougiosa, George D.
2020-08-24T15:31:37Z
2020-08-24T15:31:37Z
2020
0306-9877
https://doi.org/10.1016/j.mehy.2020.109759
http://hdl.handle.net/20.500.12010/12144
COVID-19, the disease caused by the novel SARS-CoV-2, a betacoronavirus structurally similar to SARS-CoV.
Based on both structural and syndromic similarities with SARS-CoV, a hypothesis is formed on SARS-CoV-2
potential to affect the host’s metabolism as part of its lifecycle. This hypothesis is evaluated by (a) exploratory
analysis of SARS-CoV/human transcriptomic interaction data and gene set enrichment analysis (b) a confirmatory, focused review of the literature based on the findings by (a). A STRING Viruses (available search for
human – SARS-CoV (NCBI taxonomy Id: 9606 vs. NCBI taxonomy Id: 694009) genomic interactions reveals ten
human proteins, interacting with SARS-CoV: SGTA, FGL2, SPECC1, STAT3, PHB, BCL2L1, PPP1CA, CAV1, JUN,
XPO1. Gene set enrichment analyses (GSEA) with STRING on this network revealed their role as a putative
protein – protein interaction network (PPI; Enrichment p-value = 0.0296) mediating, viral parasitism, interleukin as well as insulin signaling, diabetes and triglyceride catabolism. In the literature, SARS-CoV has been
known to cause de novo diabetes by ACE2-dependent uptake on pancreatic isle cells, and furthermore dysregulate lipid autophagy in favor of the viral lifecycle. Conversely, currently there are only non-causative, observational evidence of worse outcomes for COVID-19 patients with comorbid diabetes or hyperglycemia. No
study has reported on the lipid profiles of COVID-19 patients; however, lipid-targeting molecules have been
proposed as agents against SARS-CoV-2. Future studies, reporting on lipid and glucose metabolism of COVID-19
patients could help elucidate the disease’s seculae and aid drug design.
3 páginas
image/jepg
eng
Medical Hypotheses
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
COVID-19
SARS-CoV
SARS-CoV-2
Gene set enrichment analysis
Diabetes
Triglycerides
Viruses
A data-driven hypothesis on the epigenetic dysregulation of host metabolism by SARS coronaviral infection: Potential implications for the SARS-CoV-2 modus operandi
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/embargoedAccess
info:eu-repo/semantics/acceptedVersion
Acceso restringido
https://doi.org/10.1016/j.mehy.2020.109759
http://purl.org/coar/resource_type/c_2df8fbb1