Sanchez-Ramirez, Diana C.
Mackey, Denise
2020-08-05T14:57:44Z
2020-08-05T14:57:44Z
2020
0954-6111
https://doi.org/10.1016/j.rmed.2020.106096
http://hdl.handle.net/20.500.12010/11636
Background: An outbreak of Corona Virus Disease 2019 (COVID-19) has spread rapidly reaching
over 3 million of confirmed cases worldwide. The association of respiratory diseases and
smoking, both highly prevalent globally, with COVID-19 severity has not been elucidated. Given
the gap in the evidence and the growing prevalence of COVID-19, the objective of this study
was to explore the association of underlying respiratory diseases and smoking with severe
outcomes in patients with COVID-19 infection.
Methods: A systematic search was performed to identify studies reporting prevalence of
respiratory diseases and/or smoking in relation with disease severity in patients with confirm
COVID-19, published between January 1 to April 15, 2020 in English language. Pooled oddsratio (OR) and 95% confidence intervals (95% CI) were calculated.
Findings: Twenty two studies met the inclusion criteria. All the studies presented data of 13,184
COVID-19 patients (55% males). Patients with severe outcomes were older and a larger
percentage were males compared with the non-severe. Pooled analysis showed that prevalence
of respiratory diseases (OR 4.21; 95% CI, 2.9-6.0) and smoking (current smoking OR 1.98; 95%
CI, 1.16-3.39 and former smoking OR 3.46; 95% CI, 2.46-4.85) were significantly associated with
severe COVID-19 outcomes.
Interpretation: Results suggested that underlying respiratory diseases, specifically COPD, and
smoking were associated with severe COVID-19 outcomes. These findings may support the
planning of preventive interventions and could contribute to improvements in the assessment
and management of patient risk factors in clinical practice, leading to the mitigation of severe
outcomes in patients with COVID-19 infection.
31 páginas
image/jepg
Science Direct
Respiratory Medicine
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
COVID-19
COPD
Underlying respiratory diseases, specifically COPD, and smoking are associated with severe COVID-19 outcomes: A systematic review and meta-analysis
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/acceptedVersion
https://doi.org/10.1016/j.rmed.2020.106096