Satici, Celal
Altunok, Elif Sargin
Calik, Mustafa
Zuhal Cavus
Esatoglu, Sinem Nihal
2020-07-29T21:25:38Z
2020-07-29T21:25:38Z
2020-06-10
1201-9712
https://www.ijidonline.com/article/S1201-9712(20)30473-2/fulltext#%20
http://hdl.handle.net/20.500.12010/11382
6 páginas
application/pdf
International Journal of Infectious Diseases
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Pneumonia
CURB-65
Pneumonia severity index
Prognosis
Mortality
Performance of pneumonia severity index and CURB-65 in predicting 30-day mortality in patients with COVID-19
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
https://doi.org/10.1016/j.ijid.2020.06.038
Objective
The aim of the study was to analyze the usefulness of CURB-65 and the pneumonia severity index (PSI) in predicting 30-day mortality in patients with COVID-19, and to identify other factors associated with higher mortality.
Methods
A retrospective study was performed in a pandemic hospital in Istanbul, Turkey, which included 681 laboratory-confirmed patients with COVID-19. Data on characteristics, vital signs, and laboratory parameters were recorded from electronic medical records. Receiver operating characteristic analysis was used to quantify the discriminatory abilities of the prognostic scales. Univariate and multivariate logistic regression analyses were performed to identify other predictors of mortality.
Results
Higher CRP levels were associated with an increased risk for mortality (OR: 1.015, 95% CI: 1.008–1.021; p < 0.001). The PSI performed significantly better than CURB-65 (AUC: 0.91, 95% CI: 0.88–0.93 vs AUC: 0.88, 95% CI: 0.85–0.90; p = 0.01), and the addition of CRP levels to PSI did not improve the performance of PSI in predicting mortality (AUC: 0.91, 95% CI: 0.88–0.93 vs AUC: 0.92, 95% CI: 0.89–0.94; p = 0.29).
Conclusion
In a large group of hospitalized patients with COVID-19, we found that PSI performed better than CURB-65 in predicting mortality. Adding CRP levels to PSI did not improve the 30-day mortality prediction.