Silva, Beatriz S.C.
DiGiovanni, Laura
Kumar, Rechal
Carmichael, Ruth E.
Kim, Peter K.
Schrader, Michael
2020-07-28T19:32:26Z
2020-07-28T19:32:26Z
2020-07-23
0167-4889
https://www.sciencedirect.com/science/article/pii/S0167488920301580?via%3Dihub#!
http://hdl.handle.net/20.500.12010/11295
74 páginas
application/pdf
BBA - Molecular Cell Research
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Contactos sociales
Maintaining social contacts: The physiological relevance of organelle interactions
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
Acyl-CoA binding domain containing protein
Peroxisomes
Mitochondria
Lipid metabolism
Membrane contact sites
FFAT motif
https://doi.org/10.1016/j.bbamcr.2020.118800
Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate and facilitate cellular functions. The formation of close contacts, termed “membrane contact sites” (MCSs), represents an intriguing strategy for organelle interaction and coordinated interplay. Emerging research is rapidly revealing new details of MCSs. They represent ubiquitous and diverse structures, which are important for many aspects of cell physiology and homeostasis. Here, we provide a comprehensive overview of the physiological relevance of organelle contacts. We focus on mitochondria, peroxisomes, the Golgi complex and the plasma membrane, and discuss the most recent findings on their interactions with other subcellular organelles and their multiple functions, including membrane contacts with the ER, lipid droplets and the endosomal/lysosomal compartment.