Graham, N.S.N.
Junghans, C.
Downes, R.
Sendall, C.
Lai, H.
McKirdy, A.
Elliott, P.
Howard, R.
Wingfield, D.
Priestman, M.
Ciechonska, M.
Cameron, L.
Storch, M.
Crone, M.A.
Freemontl, P.S.
Randell, P.
McLaren, R.
Lang, N.
Ladhani, S.
Sanderson, F.
Sharp, D.J.
2020-07-24T14:37:28Z
2020-07-24T14:37:28Z
2020
0163-4453
https://doi.org/10.1016/j.jinf.2020.05.073
http://hdl.handle.net/20.500.12010/11076
Objectives: To understand SARS-Co-V-2 infection and transmission in UK nursing homes in order to develop preventive strategies for protecting the frail elderly residents.
Methods: An outbreak investigation involving 394 residents and 70 staff, was carried out in 4 nursing
homes affected by COVID-19 outbreaks in central London. Two point-prevalence surveys were performed
one week apart where residents underwent SARS-CoV-2 testing and had relevant symptoms documented.
Asymptomatic staff from three of the four homes were also offered SARS-CoV-2 testing.
Results: Overall, 26% (95% CI 22–31) of residents died over the two-month period. All-cause mortality
increased by 203% (95% CI 70–336) compared with previous years. Systematic testing identified 40% (95%
CI 35–46) of residents as positive for SARS-CoV-2, and of these 43% (95% CI 34–52) were asymptomatic
and 18% (95% CI 11–24) had only atypical symptoms; 4% (95% CI −1 to 9) of asymptomatic staff also
tested positive.
Conclusions: The SARS-CoV-2 outbreak in four UK nursing homes was associated with very high infection
and mortality rates. Many residents developed either atypical or had no discernible symptoms. A number of asymptomatic staff members also tested positive, suggesting a role for regular screening of both
residents and staff in mitigating future outbreaks.
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Journal of Infection
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Coronavirus
COVID-19
SARS-CoV-2
Nursing home
Care home
Diagnostic testing
SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
https://doi.org/10.1016/j.jinf.2020.05.073