Rodriguez-Morales, Alfonso J.
Cardona-Ospina, Jaime A.
Gutiérrez-Ocampo, Estefanía
Villamizar-Peña, Rhuvi
Holguin-Rivera, Yeimer
Escalera-Antezana, Juan Pablo
Alvarado-Arnez, Lucia Elena
Bonilla-Aldana, D. Katterine
Franco-Paredes, Carlos
Henao-Martinez, Andrés F.
Paniz-Mondolf, Alberto
Lagos-Grisales, Guillermo J.
Ramírez-Vallejo, Eduardo
Suárez, Jose A.
Zambrano, Lysien I.
Villamil-Gómez, Wilmer E.
Balbin-Ramon, Graciela J.
Rabaan, Ali A.
Harapan, Harapan
Dhama, Kuldeep
Nishiura, Hiroshi
Kataoka, Hiromitsu
Ahmad, Tauseef
Sah, Ranjit
2020-07-16T20:40:38Z
2020-07-16T20:40:38Z
2020
1477-8939
https://doi.org/10.1016/j.tmaid.2020.101623
http://hdl.handle.net/20.500.12010/10701
Introduction: An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to
a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have
been partially characterized in some observational studies. No systematic reviews on COVID-19 have been
published to date.
Methods: We performed a systematic literature review with meta-analysis, using three databases to assess
clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and
also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis
to calculate pooled prevalences and 95% confidence intervals (95%CI).
Results: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were
selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally,
39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI
84.5–92.9%), cough (57.6%, 95%CI 40.8–74.4%) and dyspnea (45.6%, 95%CI 10.9–80.4%) were the most
prevalent manifestations. Among the patients, 20.3% (95%CI 10.0–30.6%) required intensive care unit (ICU),
32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7–51.8), 6.2% (95%CI 3.1–9.3)
with shock. Some 13.9% (95%CI 6.2–21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR).
Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities.
ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was
associated with a CFR of > 13%. As this virus spreads globally, countries need to urgently prepare human
resources, infrastructure and facilities to treat severe COVID-19.
13 páginas
image/jepg
Science Direct
reponame:Expeditio Repositorio Institucional UJTL
instname:Universidad de Bogotá Jorge Tadeo Lozano
Coronavirus disease 2019
SARS-CoV-2
Clinical features
Laboratory
Outcomes
Epidemic
Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis
Artículo
Síndrome respiratorio agudo grave
COVID-19
SARS-CoV-2
Coronavirus
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/acceptedVersion
https://doi.org/10.1016/j.tmaid.2020.101623