SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

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dc.creatorSungnak, Waradon
dc.creatorHuang, Ni
dc.creatorBécavin, Christophe
dc.creatorBerg, Marijn
dc.creatorQueen, Rachel
dc.creatorLitvinukova, Monika
dc.creatorTalavera-López, Carlos
dc.creatorMaatz, Henrike
dc.creatorReichart, Daniel
dc.creatorSampaziotis, Fotios
dc.creatorWorlock, Kaylee B.
dc.creatorYoshida, Masahiro
dc.creatorBarnes, Josephine L.
dc.creatorBanovich, Nicholas E.
dc.creatorBarbry, Pascal
dc.creatorBrazma, Alvis
dc.creatorCollin, Joseph
dc.creatorDesai, Tushar J.
dc.creatorDuong, Thu Elizabeth
dc.creatorEickelberg, Oliver
dc.creatorFalk, Christine
dc.creatorFarzan, Michael
dc.creatorGlass, Ian
dc.creatorGupta, Ravindra K.
dc.creatorHaniffa, Muzlifah
dc.creatorHorvath, Peter
dc.creatorHubner, Norbert
dc.creatorHung, Deborah
dc.creatorKaminski, Naftali
dc.creatorKrasnow, Mark
dc.creatorKropski, Jonathan A.
dc.creatorKuhnemund, Malte
dc.creatorLako, Majlinda
dc.creatorLee, Haeock
dc.creatorLeroy, Sylvie
dc.creatorLinnarson, Sten
dc.creatorLundeberg, Joakim
dc.creatorMeyer, Kerstin B.
dc.creatorMiao, Zhichao
dc.creatorMisharin, Alexander V.
dc.creatorNawijn, Martijn C.
dc.creatorNikolic, Marko Z.
dc.creatorNoseda, Michela
dc.creatorOrdovas-Montanes, Jose
dc.creatorOudit, Gavin Y.
dc.creatorPe’er, Dana
dc.creatorPowell, Joseph
dc.creatorQuake, Steve
dc.creatorRajagopal, Jay
dc.creatorTata, Purushothama Rao
dc.creatorRawlins, Emma L.
dc.creatorRegev, Aviv
dc.creatorReyfman, Paul A.
dc.creatorRozenblatt-Rosen, Orit
dc.creatorSaeb-Parsy, Kourosh
dc.creatorSamakovlis, Christos
dc.creatorSchiller, Herbert B.
dc.creatorSchultze, Joachim L.
dc.creatorSeibold, Max A.
dc.creatorSeidman, Christine E.
dc.creatorSeidman, Jonathan G.
dc.creatorShalek, Alex K.
dc.creatorShepherd, Douglas
dc.creatorSpence, Jason
dc.creatorSpira, Avi
dc.creatorSun, Xin
dc.creatorTeichmann, Sarah A.
dc.creatorTheis, Fabian J.
dc.creatorTsankov, Alexander M.
dc.creatorVallier, Ludovic
dc.creatorvan den Berge, Maarten
dc.creatorWhitsett, Jeffrey
dc.creatorXavier, Ramnik
dc.creatorXu, Yan
dc.creatorZaragosi, Laure Emmanuelle
dc.creatorZerti, Darin
dc.creatorZhang, Hongbo
dc.creatorZhang, Kun
dc.creatorRojas, Mauricio
dc.creatorFigueiredo, Francisco
dc.date.accessioned2020-07-17T22:24:32Z
dc.date.available2020-07-17T22:24:32Z
dc.date.created2020-04-23
dc.description.abstractenglishWe investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.spa
dc.format.extent14 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41591-020-0868-6spa
dc.identifier.issn1546-170Xspa
dc.identifier.otherhttps://www.nature.com/articles/s41591-020-0868-6spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10814
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectCélulas epiteliales nasalesspa
dc.subject.keywordNasal epithelial cellsspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleSARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genesspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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