ACE2 enhance viral infection or viral infection aggravate the underlying diseases
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2020
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Computational and Structural Biotechnology Journal
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Resumen
ACE2 plays a critical role in SARS-CoV-2 infection to cause COVID-19 and SARS-CoV-2 spike protein binds to ACE2 and probably functionally inhibits ACE2 to aggravate the underlying diseases of COVID-19. The important factors that affect the severity and fatality of COVID-19 include patients’ underlying diseases and ages. Therefore, particular care to the patients with underlying diseases is needed during the treatment of COVID-19 patients.
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Coronavirus Infectious Disease-19, Severe Acute Respiratory Syndrome, Coronavirus 2, Angiotensin converting enzyme 2, Single Nucleotide Polymorphism, Underlying diseases, Health disparity