Association of inflammatory markers with the severity of COVID-19: A meta-analysis

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dc.creatorZeng, Furong
dc.creatorHuang, Yuzhao
dc.creatorGuo, Ying
dc.creatorYin, Mingzhu
dc.creatorChen, Xiang
dc.creatorXiao, Liang
dc.creatorDeng, Guangtong
dc.date.accessioned2020-07-23T15:21:54Z
dc.date.available2020-07-23T15:21:54Z
dc.date.created2020-07
dc.description.abstractenglishObjectives Studies reported associations of inflammatory markers with the severity of COVID-19, but conclusions were inconsistent. We aimed to provide an overview of the association of inflammatory markers with the severity of COVID-19. Methods We searched PubMed, Embase, Cochrane Library, Wanfang and China National Knowledge Infrastructure (CNKI) database until March 20, 2020. Weighted mean difference (WMD) and 95% confidence intervals (CIs) were pooled using random or fixed-effects models. Results A total of 16 studies comprising 3962 patients with COVID-19 were included in our analysis. Random-effect results demonstrated that patients with COVID-19 in the nonsevere group had lower levels for CRP (WMD = −41.78 mg/l, 95% CI = [−52.43, −31.13], P < 0.001), PCT (WMD = −0.13 ng/ml, 95% CI = [−0.20, −0.05], P < 0.001), IL-6 (WMD = −21.32 ng/l, 95% CI = [−28.34, −14.31], P < 0.001), ESR (WMD = −8 mm/h, 95% CI = [−14, −2], P = 0.005), SAA (WMD = −43.35 μg/ml, 95% CI = [−80.85, −5.85], P = 0.020) and serum ferritin (WMD = −398.80 mg/l, 95% CI = [−625.89, −171.71], P < 0.001), compared with those in the severe group. Moreover, survivors had a lower level of IL-6 than non-survivors (WMD = −4.80 ng/ml, 95% CI = [−5.87, −3.73], P < 0.001). These results were consistent through sensitivity analysis and publication bias assessment. Conclusions The meta-analysis highlights the association of inflammatory markers with the severity of COVID-19. Measurement of inflammatory markers might assist clinicians to monitor and evaluate the severity and prognosis of COVID-19.spa
dc.format.extent8 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2020.05.055spa
dc.identifier.issn1201-9712spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1201971220303623spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11029
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectMarcadores inflamatoriosspa
dc.subject.keywordCOVID-19spa
dc.subject.keywordSARS-CoV-2spa
dc.subject.keywordInflammatory markersspa
dc.subject.keywordSeverityspa
dc.subject.keywordMeta-analysisspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleAssociation of inflammatory markers with the severity of COVID-19: A meta-analysisspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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