Chinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysis

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dc.creatorXiong, Xingjiang
dc.creatorWang, Pengqian
dc.creatorSu, Kelei
dc.creatorCho, William C.
dc.creatorXing, Yanwei
dc.date.accessioned2020-08-25T21:42:50Z
dc.date.available2020-08-25T21:42:50Z
dc.date.created2020-10
dc.description.abstractenglishCurrently, coronavirus disease 2019 (COVID-19), which can lead to severe respiratory failure and death, is now a global pandemic with no specific anti-viral drugs or vaccines. However, It is worth noting that traditional Chinese medicine (TCM), especially Chinese herbal medicine (CHM), has been widely applied in mainland China since outbreak, bringing new hope for the prevention and control of COVID-19. A comprehensive literature searching was conducted in 7 electronic databases from their inception up to June 21, 2020 to evaluate the efficacy and safety of CHM for COVID-19. Eighteen randomized controlled trials (RCTs) involving 2275 patients were enrolled. Most of CHMs were originated from classical Chinese herbal formulas. Liquoric Root (Gancao, Radix Glycyrrhizae), Baical Skullcap Root (Huangqin, Radix Scutellariae Baicalensis), Pinellia Rhizome (Banxia, Rhizoma Pinelliae Tematae), Forsythia Fruit (Lianqiao, Fructus Forsythiae Suspensae), and Bitter Apricot Seed (Kuxingren, Semen Armeniacae Amarum) were most frequently used Chinese herbs. The most commonly used dosage formulation was decoction. Our meta-analyses found that comparing CHM group and conventional western medicine group, CHM group has improvements in several clinical parameters including lung CT, clinical cure rate, ranging from mild to critical cases, length of hospital stay, total score of clinical symptoms, fever reduction time, symptom score of fever, number of cough reduction cases, symptom score of cough, number of fatigue reduction cases, symptom score of fatigue, disappearing time of fatigue, TCM syndrome, viral nucleic acid testing, and inflammatory biomarkers (C-reactive protein). Besides, no severe adverse effects was identified by CHM. CHM, especially classical Chinese herbal formulas, could be used as potential candidates for COVID-19 in this battle.spa
dc.format.extent17 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.phrs.2020.105056spa
dc.identifier.issn1043-6618spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1043661820313645?via%3Dihubspa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/12263
dc.language.isoengspa
dc.publisherPharmacological Researchspa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.rights.localAcceso restringidospa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectMedicina herbal chinaspa
dc.subjectMedicina tradicional chinaspa
dc.subject.keywordChinese herbal medicinespa
dc.subject.keywordTraditional Chinese medicinespa
dc.subject.keywordCoronavirus disease 2019spa
dc.subject.keywordRandomized controlled trialspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordMeta-analysisspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleChinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysisspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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