Emerging immune functions of non-hematopoietic stromal cells

Mueller, Christopher G.; Kaye, Paul; Coles, Mark C.; Ludewig, Burkhard

doi:10.3389/978-2-88919-362-2

Emerging immune functions of non-hematopoietic stromal cells

dc.creator	Mueller, Christopher G.
dc.creator	Kaye, Paul
dc.creator	Coles, Mark C.
dc.creator	Ludewig, Burkhard
dc.date.accessioned	2020-10-13T17:44:10Z
dc.date.available	2020-10-13T17:44:10Z
dc.date.created	2014
dc.description.abstractenglish	The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology.	spa
dc.format.extent	162 páginas	spa
dc.format.mimetype	application/pdf	spa
dc.identifier.doi	10.3389/978-2-88919-362-2
dc.identifier.isbn	978-2-889-19362-2
dc.identifier.issn	1664-8714
dc.identifier.other	https://www.frontiersin.org/research-topics/463/emerging-immune-functions-of-non-hematopoietic-stromal-cells
dc.identifier.uri	https://hdl.handle.net/20.500.12010/14405
dc.language.iso	eng	spa
dc.publisher	Frontiers Media SA	spa
dc.relation.references	MuellerCGandColesMC(2014)Emergingimmunefunctionsofnon-hematopoieticstromalcells.Front.Immunol. 5:437. doi:10.3389/fimmu.2014.00437
dc.rights.accessrights	info:eu-repo/semantics/openAccess	spa
dc.rights.creativecommons	https://creativecommons.org/licenses/by/4.0/legalcode
dc.rights.local	Abierto (Texto Completo)	spa
dc.subject	Medicina	spa
dc.subject.lemb	Células estromales	spa
dc.subject.lemb	Células reticulares fibroblásticas	spa
dc.subject.lemb	Tejido linfoide
dc.title	Emerging immune functions of non-hematopoietic stromal cells	spa
dc.type.coar	http://purl.org/coar/resource_type/c_2f33	spa
dc.type.local	Libro	spa

Archivos

Bloque original

Mostrando 1 - 1 de 1

Nombre:: Emerging immune functions of non-hematopoietic stromal cells_62.PDF
Tamaño:: 16.58 MB
Formato:: Adobe Portable Document Format
Descripción:: Ver documento

Descargar

Bloque de licencias

Mostrando 1 - 1 de 1

Nombre:: license.txt
Tamaño:: 2.87 KB
Formato:: Item-specific license agreed upon to submission
Descripción:

Descargar

Colecciones

Facultad de Ciencias Naturales e Ingeniería