Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?

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dc.creatorAbeygunasekera, Anuruddha
dc.creatorJayasinghe, Saroj
dc.date.accessioned2020-07-15T01:14:40Z
dc.date.available2020-07-15T01:14:40Z
dc.date.created2020-10
dc.description.abstractenglishSARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.spa
dc.format.extent2 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.mehy.2020.109843spa
dc.identifier.issn0306-9877spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S0306987720305636?via%3Dihubspa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10531
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectDroga antifilarialspa
dc.subject.keywordSARS-CoV-2spa
dc.subject.keywordCoronaspa
dc.subject.keywordCOVID-19spa
dc.subject.keywordDiethyl carbamazine DECspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleIs the anti-filarial drug diethylcarbamazine useful to treat COVID-19?spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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