Risk factors for death in 1859 subjects with COVID-19

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dc.creatorChen, Lei
dc.creatorYu, Jianming
dc.creatorHe, Wenjuan
dc.creatorChen, Li
dc.creatorYuan, Guolin
dc.creatorDong, Fang
dc.creatorChen, Wenlan
dc.creatorCao, Yulin
dc.creatorYang, Jingyan
dc.creatorCai, Liling
dc.creatorWu, Di
dc.creatorRan, Qijie
dc.creatorLi, Lei
dc.creatorLiu, Qiaomei
dc.creatorRen, Wenxiang
dc.creatorGao, Fei
dc.creatorWang, Hongxiang
dc.creatorChen, Zhichao
dc.creatorPeter Gale, Robert
dc.creatorLi, Qiubai
dc.creatorHu, Yu
dc.date.accessioned2020-07-17T14:14:32Z
dc.date.available2020-07-17T14:14:32Z
dc.date.created2020-06-16
dc.description.abstractenglishWe studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 per year increase; P < 0.001); (2) smoking (HR = 1.84 [1.17, 2.92]; P = 0.009); (3) admission temperature per °C increase (HR = 1.32 [1.07, 1.64]; P = 0.009); (4) Log10 neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19]; P < 0.001); (5) platelets per 10 E + 9/L decrease (HR = 0.996 [0.994, 0.998]; P = 0.001); (6) activated partial thromboplastin (aPTT) per second increase (HR = 1.04 [1.02, 1.05]; P < 0.001); (7) Log10 D-dimer per mg/l increase (HR = 3.00 [2.17, 4.16]; P < 0.001); and (8) Log10 serum creatinine per μmol/L increase (HR = 4.55 [2.72, 7.62]; P < 0.001). In piecewise linear regression analyses Log10NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19.spa
dc.format.extent11 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41375-020-0911-0spa
dc.identifier.issn1476-5551 (online)spa
dc.identifier.otherhttps://www.nature.com/articles/s41375-020-0911-0spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10717
dc.publisherLeukemiaeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectRisk factors for deathspa
dc.subjectWuhanspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleRisk factors for death in 1859 subjects with COVID-19spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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