Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke
| dc.creator | Lin, Chen | |
| dc.creator | Arevalo, Yurany A. | |
| dc.creator | Nanavati, Hely D. | |
| dc.creator | Lin, Diana M. | |
| dc.date.accessioned | 2020-09-21T16:38:06Z | |
| dc.date.available | 2020-09-21T16:38:06Z | |
| dc.date.created | 2020-07-06 | |
| dc.description.abstractenglish | Objective To describe the difference in clinical presentation, including race, of ischemic stroke between patients with and without novel coronavirus disease 2019 (COVID-19), and the association of inflammatory response with stroke severity. Methods This is a retrospective, observational, cross-sectional study of patients (n = 60) admitted with ischemic stroke between late March and early May 2020. All patients were tested for COVID-19 during admission. Demographic, clinical, and laboratory data was collected through electronic medical record review. Descriptive statistics was performed to observe the differences between stroke patients with and without COVID-19 Results 60 hospitalized patients with acute ischemic stroke were included in the analysis. Nine were positive for COVID-19. African-Americans comprised of 55.6% of those that had COVID-19 and stroke and 37.7% of those with only stroke. Stroke patients with COVID-19 had a significantly higher NIHSS [18.4 (8.8)] and neutrophil-to-lymphocyte ratio (NLR) [7.3 (4.2) vs 3.8 (2.8); P = 0.0137] than those without. Those with COVID-19 also had a significantly higher mortality rate (44.4% vs. 7.6%; p < 0.001). Conclusion We observed a cohort of patients, including a large proportion of African-Americans, who developed ischemic stroke with or without COVID-19. An exaggerated inflammatory response, as indicated by NLR, likely plays a role in stroke severity among COVID-19 patients that concurrently develop ischemic stroke. | spa |
| dc.format.extent | 4 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.doi | https://doi.org/10.1016/j.bbih.2020.100137 | spa |
| dc.identifier.issn | 2666-3546 | spa |
| dc.identifier.other | https://www.sciencedirect.com/science/article/pii/S2666354620301022?via%3Dihub | spa |
| dc.identifier.uri | https://hdl.handle.net/20.500.12010/13499 | |
| dc.language.iso | eng | spa |
| dc.publisher | Brain, Behavior, & Immunity - Health | spa |
| dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | spa |
| dc.rights.local | Acceso restringido | spa |
| dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
| dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
| dc.subject | Stroke | spa |
| dc.subject | Coronavirus immune response | spa |
| dc.subject | Neutrophil-to-lymphocyte ratio | spa |
| dc.subject | Racial disparities | spa |
| dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
| dc.subject.lemb | COVID-19 | spa |
| dc.subject.lemb | SARS-CoV-2 | spa |
| dc.subject.lemb | Coronavirus | spa |
| dc.title | Racial differences and an increased systemic inflammatory response are seen in patients with COVID-19 and ischemic stroke | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | spa |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.type.local | Artículo | spa |
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