A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

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dc.creatorZhao, Hanjun
dc.creatorTo, Kelvin K. W.
dc.creatorSze, Kong-Hung
dc.creatorYung, Timothy Tin-Mong
dc.creatorBian, Mingjie
dc.creatorLam, Hoiyan
dc.creatorYeung, Man Lung
dc.creatorLi, Cun
dc.creatorChu, Hin
dc.creatorYuen, Kwok-Yung
dc.date.accessioned2020-09-19T16:56:22Z
dc.date.available2020-09-19T16:56:22Z
dc.date.created2020-08-25
dc.description.abstractenglishThe 2019 novel respiratory virus (SARS-CoV-2) causes COVID-19 with rapid global socioeconomic disruptions and disease burden to healthcare. The COVID-19 and previous emerging virus outbreaks highlight the urgent need for broad-spectrum antivirals. Here, we show that a defensin-like peptide P9R exhibited potent antiviral activity against pH-dependent viruses that require endosomal acidification for virus infection, including the enveloped pandemic A(H1N1)pdm09 virus, avian influenza A(H7N9) virus, coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), and the non-enveloped rhinovirus. P9R can significantly protect mice from lethal challenge by A(H1N1)pdm09 virus and shows low possibility to cause drug-resistant virus. Mechanistic studies indicate that the antiviral activity of P9R depends on the direct binding to viruses and the inhibition of virus-host endosomal acidification, which provides a proof of concept that virus-binding alkaline peptides can broadly inhibit pH-dependent viruses. These results suggest that the dual-functional virus- and host-targeting P9R can be a promising candidate for combating pH-dependent respiratory viruses.spa
dc.format.extent10 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41467-020-17986-9spa
dc.identifier.issn2041-1723spa
dc.identifier.otherhttps://www.nature.com/articles/s41467-020-17986-9spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/13490
dc.language.isospaspa
dc.publisherNature Communicationsspa
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccessspa
dc.rights.localAcceso restringidospa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectrespiratory virusesspa
dc.subjectinfluenza virusspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleA broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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