Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection

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dc.creatorPrieto-Pérez, Laura
dc.creatorFortes, José
dc.creatorSoto, Carlos
dc.creatorVidal-González, Ánxela
dc.creatorAlonso-Riaño, Marina
dc.creatorLafarga, Miguel
dc.creatorCortti, María José
dc.creatorLazaro-Garcia, Alberto
dc.creatorPérez-Tanoira, Ramón
dc.creatorTrascasa, Álvaro
dc.creatorAntonio, Anabel
dc.creatorCórdoba, Raúl
dc.creatorRodríguez-Pinilla, Socorro María
dc.creatorCedeño, Oderay
dc.creatorPeces-Barba, Germán
dc.creatorFernández-Ormaechea, Itziar
dc.creatorDíez Medrano, María José
dc.creatorLópez de Las Heras, Marta
dc.creatorCabello, Alfonso
dc.creatorPetkova, Elizabet
dc.creatorÁlvarez, Beatriz
dc.creatorCarrillo, Irene
dc.creatorSilva, Andrés M.
dc.creatorCastellanos, Marina
dc.creatorCalpena, Silvia
dc.creatorValverde-Monge, Marcela
dc.creatorFresneda, Diana
dc.creatorRubio-Martín, Rafael
dc.creatorCornejo, Ignacio
dc.creatorAstilleros Blanco de Cordova, Laura
dc.creatorDe la Fuente, Soraya
dc.creatorRecuero, Sheila
dc.creatorGórgolas, Miguel
dc.creatorPiris, Miguel A.
dc.date.accessioned2020-07-16T16:30:50Z
dc.date.available2020-07-16T16:30:50Z
dc.date.created2020-07-03
dc.description.abstractenglishThe spectrum of COVID-19 infection includes acute respiratory distress syndrome (ARDS) and macrophage activation syndrome (MAS), although the histological basis for these disorders has not been thoroughly explored. Post-mortem pulmonary and bone marrow biopsies were performed in 33 patients. Samples were studied with a combination of morphological and immunohistochemical techniques. Bone marrow studies were also performed in three living patients. Bone marrow post-mortem studies showed striking lesions of histiocytic hyperplasia with hemophagocytosis (HHH) in most (16/17) cases. This was also observed in three alive patients, where it mimicked the changes observed in hemophagocytic histiocytosis. Pulmonary changes included a combination of diffuse alveolar damage with fibrinous microthrombi predominantly involving small vessels, in particular the alveolar capillary. These findings were associated with the analytical and clinical symptoms, which helps us understand the respiratory insufficiency and reveal the histological substrate for the macrophage activation syndrome-like exhibited by these patients. Our results confirm that COVID-19 infection triggers a systemic immune-inflammatory disease and allow specific therapies to be proposed.spa
dc.format.extent8 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41379-020-0613-1spa
dc.identifier.issn1530-0285 (online)spa
dc.identifier.otherhttps://www.nature.com/articles/s41379-020-0613-1spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/10666
dc.publisherModern Pathologyeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectHistiocytic hyperplasiaspa
dc.subjectHistiocytic hyperplasia with hemophagocytosispa
dc.subjectacute alveolar damage in COVID-19 infectionspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleHistiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infectionspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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