Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored

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dc.creatorFan, Hua
dc.creatorZhang, Lin
dc.creatorHuang, Bin
dc.creatorZhu, Muxin
dc.creatorZhou, Yong
dc.creatorZhang, Huan
dc.creatorTao, Xiaogen
dc.creatorCheng, Shaohui
dc.creatorYu, Wenhu
dc.creatorZhu, Liping
dc.creatorChen, Jian
dc.date.accessioned2020-07-23T14:43:05Z
dc.date.available2020-07-23T14:43:05Z
dc.date.created2020-07
dc.description.abstractenglishObjective To describe the clinical features of coronavirus disease 2019 (COVID-19). Methods We recruited 73 patients with COVID-19 [49 men and 24 women; average age: 58.36 years (SD: 14.31)] admitted to the intensive care unit of Wuhan Jinyintan Hospital from December 30, 2019 to February 16, 2020. Demographics, underlying diseases, and laboratory test results on admission were collected and analyzed. Data were compared between survivors and non-survivors. Results The non-survivors were older (65.46 [SD 9.74]vs 46.23 [12.01]) and were more likely to have chronic medical illnesses. Non-survivors tend to develop more severe lymphopenia, with higher C-reactive protein, interleukin-6, D-dimer, and hs-Troponin I(hs-TnI) levels. Patients with elevated hs-TnI levels on admission had shorter duration from symptom onset to death. Increased hs-TnI level was related to dismal prognosis. Death risk increased by 20.8% when the hs-TnI level increased by one unit. After adjusting for inflammatory or coagulation index, the independent predictive relationship between hs-TnI and death disappeared. Conclusions Cardiac injury may occur at the early stage of COVID-19, which is associated with high mortality. Inflammatory factor cascade and coagulation abnormality may be the potential mechanisms of COVID-19 combined with cardiac injury.spa
dc.format.extent4 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2020.05.024spa
dc.identifier.issn1201-9712spa
dc.identifier.otherhttps://www.sciencedirect.com/science/article/pii/S1201971220303313#kwd0005spa
dc.identifier.urihttps://hdl.handle.net/20.500.12010/11018
dc.publisherScience Directeng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.sourcereponame:Expeditio Repositorio Institucional UJTLspa
dc.sourceinstname:Universidad de Bogotá Jorge Tadeo Lozanospa
dc.subjectLesión cardiacaspa
dc.subject.keywordSevere acute respiratory syndrome coronavirus 2spa
dc.subject.keywordCoronavirus diseasespa
dc.subject.keywordCardiac injuryspa
dc.subject.lembSíndrome respiratorio agudo gravespa
dc.subject.lembCOVID-19spa
dc.subject.lembSARS-CoV-2spa
dc.subject.lembCoronavirusspa
dc.titleCardiac injuries in patients with coronavirus disease 2019: Not to be ignoredspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.type.localArtículospa

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