Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
| dc.creator | Liao, Mingfeng | |
| dc.creator | Liu, Yang | |
| dc.creator | Yuan, Jing | |
| dc.creator | Wen, Yanling | |
| dc.creator | Xu, Gang | |
| dc.creator | Zhao, Juanjuan | |
| dc.creator | Cheng, Lin | |
| dc.creator | Li, Jinxiu | |
| dc.creator | Wang, Xin | |
| dc.creator | Wang, Fuxiang | |
| dc.creator | Liu, Lei | |
| dc.creator | Amit, Ido | |
| dc.creator | Zhang, Shuye | |
| dc.creator | Zhang, Zheng | |
| dc.date.accessioned | 2020-07-17T20:38:12Z | |
| dc.date.available | 2020-07-17T20:38:12Z | |
| dc.date.created | 2020-05-12 | |
| dc.description.abstractenglish | Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19. | spa |
| dc.format.extent | 15 páginas | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.doi | https://doi.org/10.1038/s41591-020-0901-9 | spa |
| dc.identifier.issn | 1546-170X | spa |
| dc.identifier.other | https://www.nature.com/articles/s41591-020-0901-9#article-info | spa |
| dc.identifier.uri | https://hdl.handle.net/20.500.12010/10808 | |
| dc.publisher | Science Direct | eng |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.source | reponame:Expeditio Repositorio Institucional UJTL | spa |
| dc.source | instname:Universidad de Bogotá Jorge Tadeo Lozano | spa |
| dc.subject | Células inmunes | spa |
| dc.subject.keyword | Single-cell landscape | spa |
| dc.subject.keyword | Immune cells | spa |
| dc.subject.lemb | Síndrome respiratorio agudo grave | spa |
| dc.subject.lemb | COVID-19 | spa |
| dc.subject.lemb | SARS-CoV-2 | spa |
| dc.subject.lemb | Coronavirus | spa |
| dc.title | Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 | spa |
| dc.type.hasversion | info:eu-repo/semantics/acceptedVersion | spa |
| dc.type.local | Artículo | spa |
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